Drug side effects affect medication compliance in schizophrenia patients
Keywords:
schizophrenia, drug side effects, medication complianceAbstract
Schizophrenia is a chronic mental disorder characterized by impaired thinking, emotions, and behavior, requiring long-term therapy. Medication adherence is a crucial factor in preventing relapse, yet many patients remain non-compliant for various reasons, including medication side effects. This non-adherence can increase the risk of relapse, readmission, and even reduce the patient's quality of life. Therefore, this study aims to analyze the relationship between medication side effects and medication adherence in schizophrenia patients at Grhasia Hospital, Yogyakarta, in 2025. The aim of this study was to determine the side effects of drugs and the level of compliance with taking medication in schizophrenia patients, as well as to analyze the relationship between side effects of drugs and compliance with taking medication at Grhasia Hospital, Yogyakarta. This study uses a descriptive correlational quantitative method with a cross-sectional approach . The sample consisted of 93 schizophrenia patients undergoing treatment at the psychiatric clinic of Grhasia Mental Hospital, Yogyakarta, selected using the accidental technique. sampling according to inclusion and exclusion criteria. The instruments used were the Glasgow Antipsychotic Side-Effect Scale (GASS) to measure drug side effects, and the Medication Morisky Adherence Scale (MMAS-8) to measure medication adherence. Data analysis was performed using the Kendall Tau correlation test. The results of the study showed that there was a significant relationship between drug side effects and medication adherence (p = 0.025), patients with milder side effects tended to have higher adherence. This study concluded that there is a significant relationship between medication side effects and medication adherence in schizophrenia patients. The milder the side effects experienced, the higher the level of medication adherence, making side effect management a crucial factor in improving therapy success
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